Five organ systems. One hormonal event. Evidence-based protocols.
Master Class Starts
Master Class Starts
June 20, 2026
Perimenopause and Menopause: A Five-System Clinical Approach
Leslie Fuller, ND and Jillian Moehle, ND
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Why arrhythmias, brain fog, and vaginal dryness appear unrelated when they share a single cause
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Your patients heal slowly from injury during perimenopause—but imaging looks normal. What’s actually happening at the tissue level.
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The WHI study was misapplied for decades. Current data on bioidentical hormones contradicts what you were taught.
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Genitourinary syndrome affects 87% of postmenopausal women, yet only 6-7% receive treatment. Your screening protocol determines who gets helped.
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Visceral fat accelerates before hot flashes appear. Why cardiometabolic intervention works only in this narrow window.
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CLASS OVERVIEW
Five Modules That Reframe Menopause as Integrated Physiology
This course distills the clinical evidence on perimenopause and menopause into a systematic, five-system framework for assessment and treatment.
Rather than focusing on isolated symptoms, you’ll learn to recognize the neuroendocrine transition as a unified event that simultaneously affects cardiovascular, neurocognitive, genitourinary, musculoskeletal, and metabolic tissues.
Key learnings:
Rather than focusing on isolated symptoms, you’ll learn to recognize the neuroendocrine transition as a unified event that simultaneously affects cardiovascular, neurocognitive, genitourinary, musculoskeletal, and metabolic tissues.
Key learnings:
- How to distinguish menopausal changes from disease states
- Why bioidentical hormone formulations differ from WHI-era compounds
- When early intervention prevents irreversible tissue decline, and
- Which multi-system protocols produce measurable outcomes.
Leslie Fuller, ND and Jillian Moehle, ND synthesize endocrinology, evidence-based medicine, and functional assessment into clinical sequences you can implement immediately.
Fragmented Care Creates a Multi-Decade Treatment Gap
Most practitioners assess menopausal women system by system, sending them to cardiology for arrhythmias, psychiatry for mood
changes, and urogynecology for atrophy. They never connect these presentations to a single hormonal transition.
This fragmentation delays recognition of the unified event and prevents early intervention during the critical window when outcomes are most
modifiable.
Women experience unnecessary specialist referrals, trial-and-error medication protocols, and the normalization of decline they’re told is inevitable aging.
The cost?
changes, and urogynecology for atrophy. They never connect these presentations to a single hormonal transition.
This fragmentation delays recognition of the unified event and prevents early intervention during the critical window when outcomes are most
modifiable.
Women experience unnecessary specialist referrals, trial-and-error medication protocols, and the normalization of decline they’re told is inevitable aging.
The cost?
- Missed prevention of cardiovascular disease
- Cognitive decline
- Bone loss
- Musculoskeletal fragility, and more.
Without integrative assessment, you’re treating symptoms in isolation while the underlying transition progresses unchecked.
Without integrative assessment, you’re treating symptoms in isolation while the underlying transition progresses unchecked.
Did You Know...
Did You Know...
The average WHI participant was 63 years old and NOT perimenopausal, making the findings irrelevant to your 45-year-old patients.
Low-dose vaginal estrogen had its black box warning removed in November 2025 based on evidence showing zero increased cancer risk.
Women experience 10-15% LDL elevation in perimenopause independent of diet, requiring deeper risk assessment.
Visceral fat accelerates 1-2 years before the final menstrual period, creating an intervention window before it becomes metabolic disease.
Neurocognitive changes affect up to 70% of perimenopausal women but are misdiagnosed as aging, ADHD, or depression.
Musculoskeletal syndromes appear simultaneously during menopause, yet practitioners typically address each tissue type separately.
Five Modules That Connect Scattered Perimenopause Presentations to Integrated Physiology
Why do your smartest, most health-conscious patients suddenly develop brain fog, lose muscle despite exercise, gain visceral fat without
weight gain, and experience injuries that won’t heal?
This Master Class answers this question by distilling how the loss of estrogen, progesterone, and testosterone leads to predictable, multisystem physiological changes.
You’ll learn the core concept of menopause as a neuroendocrine transition rather than a disease state.
Core concepts include:
weight gain, and experience injuries that won’t heal?
This Master Class answers this question by distilling how the loss of estrogen, progesterone, and testosterone leads to predictable, multisystem physiological changes.
You’ll learn the core concept of menopause as a neuroendocrine transition rather than a disease state.
Core concepts include:
- Recognizing symptom clusters as diagnostic evidence
- Understanding why bioidentical formulations differ from older research
- Assessing all five affected systems in sequence
- Identifying the critical intervention window, and
- Implementing layered protocols that address multiple pathways simultaneously.
Fuller and Moehle, both licensed naturopathic doctors with deep clinical experience, ground each module in current evidence and practical
workflows you can start using immediately.
COURSE FEATURES
Learn the Five-System Assessment Protocol
1
Recognize Symptom Clusters as Diagnostic Evidence
Stop treating arrhythmias, brain fog, and vaginal dryness as three separate problems and start recognizing them as a unified neuroendocrine transition.
2
Distinguish WHI Misapplication From Current Evidence
Understand why 2002 data on conjugated equine estrogen doesn’t apply to today’s bioidentical formulations, clearing the way for better treatment.
3
Identify the Critical Intervention Window
Learn when early assessment and intervention prevent progression to disease versus when you’re treating established decline.
4
Build Practical Lab Assessment Sequences
Order the right tests in the right order to identify sleep disorders, thyroid dysfunction, insulin resistance, and nutrient deficiencies that amplify menopausal symptoms.
5
Construct Layered Multi-System Protocols
Move beyond single-pathway thinking to design hormone, nutritional, lifestyle, and referral sequences that address mechanisms rather than just chase symptom relief.
6
Screen Systematically Across Five Organ Systems
Develop repeatable assessment templates for cardiovascular, neurocognitive, genitourinary, musculoskeletal, and metabolic domains.
MEET YOUR INSTRUCTOR
Leslie Fuller, ND and Jillian Moehle, ND
Leslie Fuller, ND is a residency-trained naturopathic physician and full-time Professor at the University of Western States, where she teaches clinical neurology, nutrition, and laboratory assessment. With over two decades of experience in neurology and disability care, her work bridges evidence-based medicine with integrative strategies to support recovery, resilience, and cognitive health.
Clinically, Dr. Fuller specializes in neurological conditions such as Parkinson’s disease, multiple sclerosis, stroke, and spinal cord injury, as well as the hormonal transitions of perimenopause and menopause and their impact on the brain and body. She combines nutrition, botanical medicine, and lifestyle approaches to help patients and clinicians alike better understand and optimize neurologic and hormonal function.
Jillian Moehle, ND is a Naturopathic and Functional Medicine Physician based in Portland, Oregon, where she provides integrative primary care with a focus on perimenopause, menopause, and cardiometabolic health. Certified by the Institute for Functional Medicine and an active member of the North American Menopause Society, she combines root-cause investigation, lifestyle medicine, and evidence-based hormone therapy to support optimal health in midlife and beyond.
Dr. Moehle also speaks and teaches on functional approaches to women’s health and hormone replacement therapy for clinicians nationwide.
Clinically, Dr. Fuller specializes in neurological conditions such as Parkinson’s disease, multiple sclerosis, stroke, and spinal cord injury, as well as the hormonal transitions of perimenopause and menopause and their impact on the brain and body. She combines nutrition, botanical medicine, and lifestyle approaches to help patients and clinicians alike better understand and optimize neurologic and hormonal function.
Jillian Moehle, ND is a Naturopathic and Functional Medicine Physician based in Portland, Oregon, where she provides integrative primary care with a focus on perimenopause, menopause, and cardiometabolic health. Certified by the Institute for Functional Medicine and an active member of the North American Menopause Society, she combines root-cause investigation, lifestyle medicine, and evidence-based hormone therapy to support optimal health in midlife and beyond.
Dr. Moehle also speaks and teaches on functional approaches to women’s health and hormone replacement therapy for clinicians nationwide.
COURSE CONTENT
Course Session Information
Course Session Information
Five modules on perimenopause and menopause that reframe scattered symptoms as integrated physiology and teach evidence-based multi-system assessment and treatment protocols.
SESSION 1
Menopause Misrepresented
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Reframe menopause as a neuroendocrine transition affecting multiple organ systems simultaneously, not isolated complaints requiring specialist referrals.
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Analyze how the WHI study was misapplied across two decades, understand current
bioidentical formulation evidence, and identify the critical timing window for intervention.
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Assess all five affected systems in sequence to prevent fragmented care.
SESSION 2
Genitourinary Syndrome of Menopause
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Learn how to diagnose genitourinary syndrome; understanding why 87% of postmenopausal women are affected yet only 6-7% receive treatment.
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Interpret the 2025 FDA de-boxing of vaginal estrogen, including recent survival benefit data in breast cancer patients and elimination of the need for progestogen.
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Implement first-line and adjunctive treatments, including low-dose vaginal estrogen, non-hormonal moisturizers, probiotics, and pelvic floor physical therapy.
SESSION 3
Neurocognitive Concerns in Menopause
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Differentiate menopause-related cognitive impairment from psychiatric disease.
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Assess sleep disorders, thyroid dysfunction, nutrient deficiencies, metabolic dysfunction, and other factors that amplify cognitive
decline.
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Design layered protocols starting with lifestyle optimization, progressing to targeted supplementation, and pharmaceuticals for moderate-to-severe cases.
SESSION 4
Cardiometabolic Changes of Menopause
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Recognize lipid elevation, visceral fat accumulation, and vascular dysfunction that occur independent of lifestyle and diet.
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Learn to distinguish early intervention benefits from hormone therapy initiated years after menopause, informing patient selection for treatment.
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Implement protocols to counter lean muscle loss and visceral fat accumulation during this metabolic transition.
SESSION 5
Musculoskeletal Syndrome of Menopause
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Diagnose when non-traumatic, multi-site musculoskeletal pain and healing delays are potentially estrogen-driven.
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Understand changes in bone, muscle, tendon, and cartilage and recognize the critical window for building reserves.
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Design resistance-training and nutritional protocols to counter bone loss, sarcopenia, and tendinopathy.
SESSION 6
Integrated Case Application and Treatment Sequencing
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Apply the five-system assessment and learn to prioritize which system to address first.
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Sequence hormone therapy, nutritional protocols, lifestyle interventions, and specialist referrals.
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Track outcomes across all five domains using repeatable metrics so you can adjust protocols based on response rather than guesswork.
What's Included in the Course
What's Included in the Course
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Five complete video modules with Leslie Fuller, ND and Jillian Moehle, ND - Clinical assessment templates and screening tools for each organ system
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Evidence-based lab interpretation guides with ordering sequences
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Supplement and botanical dosing protocols with duration and outcome tracking
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Exercise prescription templates for cardiometabolic and musculoskeletal management
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Case studies showing protocol modification based on lab results and patient response
Online course available beginning:
June 20, 2026
Transform Your Practice...
Enroll Today!
Transform Your Practice...
Enroll Today!
Enroll Today!
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MONTHLY SUBSCRIPTION
MONTHLY SUBSCRIPTION
INSTANT SAVINGS
$399
$399
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This Course
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Monthly Master Classes taught by leading functional medicine experts
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Full Access to the Clinical Mastery Program (100 hours)
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Members-only Q&A platform
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Patient referral network
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SINGLE CLASS
SINGLE CLASS
$295
$295
3 Months Access
This Course ($395 Value) Includes:
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Stop seeing unrelated complaints and start systematically assessing the neuroendocrine transition.
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Understand exactly why current bioidentical formulations differ from 2002 WHI research and treat with confidence.
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Learn practical lab interpretation sequences, screening templates, and multi-system assessment frameworks.
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Move beyond single-pathway supplementation or pharmaceuticals to create hormone, nutritional, lifestyle, and referral sequences.
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Develop evidence-based competency in a population that represents 20-30% of your patient base and responds dramatically to appropriate early intervention.
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